STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice

STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice

STAT3 activates transcription of genes that regulate cell growth, differentiation, and survival of mammalian cells. Genetic deletion of Stat3 in T cells has been shown to abrogate Th17 differentiation, suggesting that STAT3 is a potential therapeutic target for Th17-mediated diseases. However, a maj...

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Bibliographic Details
Main Authors: Evaristus C. Mbanefo, Ming Yan, Minkyung Kang, Sahar A. Alhakeem, Yingyos Jittayasothorn, Cheng-Rong Yu, Ashutosh Parihar, Sunanda Singh, Charles E. Egwuagu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
nanobody
STAT3
Th17
uveitis
EAU
Th1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.724609/full

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