Organo-protective effects of a calcium antagonist nifedipine SR in elderly patients with isolated and systolo-diastolic arterial hypertension

• Main Authors: V. E. Oleynikov, V. A. Budanova, S. S. Fadeeva, N. A. Borisova, E. E. Grishaeva, L. I. Gusakovskaya
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 1970-01-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: elderly patients; nifedipine sr; isolated systolic arterial hypertension; hypertension; microalbuminuria; endothelial dysfunction
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1589

Aim. To study clinical effectiveness of a calcium antagonist nifedipine SR in patients with various clinical variants of Stage I-II arterial hypertension (AH), aged over 60 years.Material and methods. An open, prospective, 48-week study included 48 patients with Stage I-II AH (mean age 66,15±4,81 years). Participants with systolo-diastolic AH (SDAH) and isolated systolic AH (ISAH) received nifedipine SR (Cordaflex RD) (40 mg/d). Treatment effectiveness was assessed by the dynamics of office blood pressure (BP) measurements and 24-hour BP monitoring (BPM). Organo-protection was assessed by echocardiography parameters and microalbuminuria (MAU) level. Vasoprotection was assessed by volume sphygmography and endothelial dysfunction parameters.Results. Nifedipine SR therapy normalized circadian BP profile, reduced pressure load parameters and pulse BP, improved systolic and diastolic function, facilitated myocardial hypertrophy regression, and decreased the number of MAU individuals in both groups, especially in those with ISAH. In addition, nifedipine SR facilitated arterial remodeling regression in elderly patients: in ISAH participants, its effect was mostly targeted at elastic vessels; in SDAH individuals, on muscular vessels and endothelial dysfunction correction.Conclusion. Nifedipine SR therapy for 48 weeks demonstrated stable antihypertensive and organo-protective effects in elderly patients.