Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.

Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.

Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop...

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Bibliographic Details
Main Authors: Brian J Capaldo, Devin Roller, Mark J Axelrod, Alex F Koeppel, Emanuel F Petricoin, Craig L Slingluff, Michael J Weber, Aaron J Mackey, Daniel Gioeli, Stefan Bekiranov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4583389?pdf=render

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