The role of intestinal endotoxemia in liver failure and its complications

• Main Author: GAO Fangyuan
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2014-08-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver failure; endotoxemia; pathogenesis; hepatic encephalopathy; peritonitis; hepatorenal syndrome; review
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6035&ClassID=86141319

Recent studies have found that endotoxin not only activates immune response, exacerbates liver injury, and induces liver failure, but also plays an important role in the development of hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, and other fatal complications. The recent progress in research on the pathogenesis of intestinal endotoxemia (IETM) and its impact on the development and progression of liver failure is reviewed and summarized. It is suggested that seeking effective methods to prevent and control IETM holds promise as the key to treating severe liver disease and liver failure successfully.