Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists

G protein-coupled receptors (GPCRs) are involved in essentially all physiological processes in mammals. The classical GPCR signal transduction mechanism occurs by coupling to G protein, but it has recently been demonstrated that interaction with β-arrestins leads to activation of pathways that are i...

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Bibliographic Details
Main Authors: Geisa A Santos, Diego A Duarte, Lucas T Parreiras-e-Silva, Felipe R Teixeira, Rafael M Silva-Rocha, Eduardo B Oliveira, Michel eBouvier, Claudio M Costa-Neto
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Pharmacology
Subjects:
Signal Transduction
Medicinal Chemistry
GPCR
biased agonism
kinases.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00131/full

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