HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1

HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1

We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6’s ubiquitin E3 ligase activity. Here, we have reported HDAC6’s second potential E3 ligase substrate, a critical cell cycle checkpoint...

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Bibliographic Details
Main Authors: Niko Moses, Mu Zhang, Jheng-Yu Wu, Chen Hu, Shengyan Xiang, Xinran Geng, Yue Chen, Wenlong Bai, You-Wei Zhang, Gerold Bepler, Xiaohong Mary Zhang
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
histone deacetylase 6 (HDAC6)
checkpoint kinase 1 (Chk1)
ubiquitination
ubiquitin E3 ligase
ionizing radiation (IR)
DNA damage response (DDR)
Online Access:https://www.mdpi.com/2073-4409/9/10/2237

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https://www.mdpi.com/2073-4409/9/10/2237

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