Primary spinal epidural diffuse large B-cell lymphoma with paraplegia as the first manifestation: a case report

• Main Authors: Shu Y, Wang A, Yi L, Xu X, Yang W
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-08-01
• Series: OncoTargets and Therapy
• Subjects: epidural; diffuse large B-cell lymphoma
• Online Access: https://www.dovepress.com/primary-spinal-epidural-diffuse-large-b-cell-lymphoma-with-paraplegia--peer-reviewed-article-OTT

Yefei Shu,1 Anlong Wang,2 Li Yi,3 Xiaofeng Xu,1 Wei Yang11Department of Oncology and Hematology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of China; 2Department of Radiology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of China; 3Departments of Pathology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of ChinaAbstract: Primary spinal epidural diffuse large B-cell lymphoma (DLBCL) is rare and often easily misdiagnose. Here, we presented a case of primary spinal epidural DLBCL with paraplegia as the first manifestation. He was misdiagnosed as thoracic disc herniation and thoracic tuberculosis successively. DLBCL was confirmed after surgery ultimately. After 6 cycles of chemotherapy with R-CHOPE, the patient went back to normal life without relapse during 2-year follow-up. Primary spinal epidural lymphoma should be suspected in patients with spinal cord compression with imaging showing isointense, homogeneous extradural contiguous level compressive soft‑tissue lesion without bony involvement and previous history of cancer.Keywords: epidural, diffuse large B-cell lymphoma