Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), implying an inhibitory role of this...

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Main Authors: Xiaofang Wang, Suzhen Wang, Changcheng Li, Tian Gao, Ying Liu, Afsaneh Rangiani, Yao Sun, Jianjun Hao, Anne George, Yongbo Lu, Jay Groppe, Baozhi Yuan, Jian Q Feng, Chunlin Qin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3355082?pdf=render

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http://europepmc.org/articles/PMC3355082?pdf=render

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