Effect of locking plate internal fixation system treatment on the levels of bone turnover biomarkers and inflammatory factors in patients with proximal humeral fractures

• Main Authors: Chun-Cong Huang1, Xue-Dong Yu2, Hua-Yi Zhang1, De-Bing Yang1, Guo-Zhong Hu1, Hua Luo1, Jian Xiao1, Kai Chen1
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Proximal humeral fractures; Locking plate; Bone turnover; Inflammatory factors
• Online Access: http://www.hnykdxxb.com/PDF/201707/16.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of locking plate internal fixation system treatment on the levels of bone turnover biomarkers and inflammatory factors in patients with proximal humeral fractures. Methods: 62 patients with proximal humeral fractures who received surgical treatment in the hospital between May 2013 and February 2016 were selected and divided into the control group (n=34) who received traditional common anatomical bone plate internal fixation treatment and the observation group (n=28) who received locking plate internal fixation system treatment. 4 weeks after operation, enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of bone formation indexes, bone resorption indexes, pro-inflammatory factors and anti-inflammatory factors of two groups of patients. Results: 4 weeks after operation, serum bone formation indexes osteocalcin (OC), N-terminal propeptide of procollagen type I (P1NP), bone alkaline phosphatase (BALP) and bone gla protein (BGP) levels of observation group were higher than those of control group while bone resorption indexes pyridinoline (PYD), tartrate-resistant acid phosphatase (TRAP), cross-linked C-terminal telopeptides of type I collagen (CTX) and deoxypyridinoline crosslink (D-pyr) levels were lower than those of control group (P<0.05); serum pro-inflammatory factors interleukin 1β (IL-1β), interleukin-6 (IL-6) and interleukin-22 (IL-22) levels of observation group were lower than those of control group while anti-inflammatory factors soluble tumor necrosis factor receptor I (sTNF-RI), interleukin-4 (IL-4) and interleukin-13 (IL-13) levels were higher than those of control group (P<0.05). Conclusion: Locking plate internal fixation system treatment of proximal humeral fractures can promote the fracture end healing and improve the bone metabolism without causing strong systemic inflammatory reaction.