Comparative evaluation of blood biochemical parameters and changes of the internal organs under the influence of doxorubicin and nanostructured doxorubicin in condition of transplantable carcinogenesis (experimental Zajdela ascites hepatoma)

• Main Authors: I. N. Chairkin, O. N. Deryabina, N. V. Chairkina, I. V. Kargina, V. Yu. Medvezhonkov, A. E. Strizhkov, K. V. Bulygin
• Format: Article
• Language: Russian
• Published: Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) 2018-06-01
• Series: Сеченовский вестник
• Subjects: transplantable carcinogenesis; zaidela ascites hepatoma; nanostructured doxorubicin
• Online Access: https://www.sechenovmedj.com/jour/article/view/59
• ISSN: 2218-7332; 2658-3348

The effect of doxorubicin and nanostructured doxorubicin on biochemical parameters and parameters in the blood serum of rats under conditions of the transplanted experimental Zajdela ascitic hepatoma was studied. The use of doxorubicin is accompanied by dysfunction and inhibition of blood sprouts, and also has nephrotoxic and hepatotoxic effects, which is confirmed by changes in the biochemical parameters of blood serum while the use of nanostructured doxorubicin is accompanied by normalization of these indicators.