STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule...

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Main Authors: Yi-Ru Pan, Chih-Cheng Chen, Yu-Tien Chan, Hsiao-Jung Wang, Fan-Tso Chien, Yeng-Long Chen, Jing-Lan Liu, Muh-Hwa Yang
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06134-z
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spelling doaj-95f73b88a6d342eb9cd45626c936f80a2021-05-11T10:32:30ZengNature Publishing GroupNature Communications2041-17232018-09-019111610.1038/s41467-018-06134-zSTAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomasYi-Ru Pan0Chih-Cheng Chen1Yu-Tien Chan2Hsiao-Jung Wang3Fan-Tso Chien4Yeng-Long Chen5Jing-Lan Liu6Muh-Hwa Yang7Institute of Clinical Medicine, National Yang-Ming UniversityDivision of Hematology and Oncology, Chang Gung Memorial HospitalInstitute of Clinical Medicine, National Yang-Ming UniversityDivision of Experimental Surgery, Department of Surgery, Taipei Veterans General HospitalInstitute of Physics, Academia SinicaInstitute of Physics, Academia SinicaDepartment of Pathology, Chang Gung Memorial HospitalInstitute of Clinical Medicine, National Yang-Ming UniversityThe mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.https://doi.org/10.1038/s41467-018-06134-z
collection DOAJ
language English
format Article
sources DOAJ
author Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
spellingShingle Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
Nature Communications
author_facet Yi-Ru Pan
Chih-Cheng Chen
Yu-Tien Chan
Hsiao-Jung Wang
Fan-Tso Chien
Yeng-Long Chen
Jing-Lan Liu
Muh-Hwa Yang
author_sort Yi-Ru Pan
title STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_short STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_full STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_fullStr STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_full_unstemmed STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
title_sort stat3-coordinated migration facilitates the dissemination of diffuse large b-cell lymphomas
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.
url https://doi.org/10.1038/s41467-018-06134-z
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