STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule...

Full description

Bibliographic Details
Main Authors: Yi-Ru Pan, Chih-Cheng Chen, Yu-Tien Chan, Hsiao-Jung Wang, Fan-Tso Chien, Yeng-Long Chen, Jing-Lan Liu, Muh-Hwa Yang
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06134-z
Description
Summary:The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.
ISSN:2041-1723

Similar Items