Psychosocial Stress Induces Schizophrenia-Like Behavior in Mice With Reduced MMP-9 Activity

Psychosocial Stress Induces Schizophrenia-Like Behavior in Mice With Reduced MMP-9 Activity

Understanding gene-environment interactions in the pathogenesis of schizophrenia remains a major research challenge. Matrix metalloproteinase-9 (MMP-9) has been previously implicated in the pathophysiology of schizophrenia. In the present study, adolescent Mmp-9 heterozygous mice, with a genetically...

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Bibliographic Details
Main Authors: Behnam Vafadari, Shiladitya Mitra, Marzena Stefaniuk, Leszek Kaczmarek
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
gene × environment (G×E) interaction
schizophrenia
negative symptoms
clozapine
antipsychotic
MMP-9
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00195/full

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