Homologous recombination is unlikely to play a major role in influenza B virus evolution

<p>Abstract</p> <p>Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial. To determine the extent of homologous recombination in influenza B viruses, recombination analyses of 2,65...

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Main Authors:	Liu Xi-Ping, Han Guan-Zhu, Li Si-Shen
Format:	Article
Language:	English
Published:	BMC 2008-05-01
Series:	Virology Journal
Online Access:	http://www.virologyj.com/content/5/1/65

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spelling	doaj-95de00a86e2c43959f9849476aa973b22020-11-24T20:49:15ZengBMCVirology Journal1743-422X2008-05-01516510.1186/1743-422X-5-65Homologous recombination is unlikely to play a major role in influenza B virus evolutionLiu Xi-PingHan Guan-ZhuLi Si-Shen<p>Abstract</p> <p>Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial. To determine the extent of homologous recombination in influenza B viruses, recombination analyses of 2,650 sequences representing all eight segments of the influenza B viruses were carried out. Only four sequences were indentified as putative recombinants, which were verified using phylogenetic methods. However, the mosaics detected here were much likely to represent cases of laboratory-generated artificial recombinants. As in other myxoviruses, it is unlikely that homologous recombination plays a major role in influenza B virus evolution.</p> http://www.virologyj.com/content/5/1/65
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Liu Xi-Ping Han Guan-Zhu Li Si-Shen
spellingShingle	Liu Xi-Ping Han Guan-Zhu Li Si-Shen Homologous recombination is unlikely to play a major role in influenza B virus evolution Virology Journal
author_facet	Liu Xi-Ping Han Guan-Zhu Li Si-Shen
author_sort	Liu Xi-Ping
title	Homologous recombination is unlikely to play a major role in influenza B virus evolution
title_short	Homologous recombination is unlikely to play a major role in influenza B virus evolution
title_full	Homologous recombination is unlikely to play a major role in influenza B virus evolution
title_fullStr	Homologous recombination is unlikely to play a major role in influenza B virus evolution
title_full_unstemmed	Homologous recombination is unlikely to play a major role in influenza B virus evolution
title_sort	homologous recombination is unlikely to play a major role in influenza b virus evolution
publisher	BMC
series	Virology Journal
issn	1743-422X
publishDate	2008-05-01
description	<p>Abstract</p> <p>Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial. To determine the extent of homologous recombination in influenza B viruses, recombination analyses of 2,650 sequences representing all eight segments of the influenza B viruses were carried out. Only four sequences were indentified as putative recombinants, which were verified using phylogenetic methods. However, the mosaics detected here were much likely to represent cases of laboratory-generated artificial recombinants. As in other myxoviruses, it is unlikely that homologous recombination plays a major role in influenza B virus evolution.</p>
url	http://www.virologyj.com/content/5/1/65
work_keys_str_mv	AT liuxiping homologousrecombinationisunlikelytoplayamajorroleininfluenzabvirusevolution AT hanguanzhu homologousrecombinationisunlikelytoplayamajorroleininfluenzabvirusevolution AT lisishen homologousrecombinationisunlikelytoplayamajorroleininfluenzabvirusevolution
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Homologous recombination is unlikely to play a major role in influenza B virus evolution

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