Complement Activation Is Associated With Crescents in IgA Nephropathy

Complement Activation Is Associated With Crescents in IgA Nephropathy

IntroductionCrescents, especially those found at a percentage greater than 50%, are often associated with rapid progression of kidney disease in IgA nephropathy (IgAN). The mechanism of crescents forming in IgAN is still unclear. In this study, we aimed to evaluate whether excess complement activati...

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Bibliographic Details
Main Authors: Zi Wang, Xinfang Xie, Jingyi Li, Xue Zhang, Jiawei He, Manliu Wang, Jicheng Lv, Hong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin A nephropathy (IgAN)
crescent
complement
lectin pathway
urinary C4d
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676919/full

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