NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.

Bibliographic Details
Main Authors:	Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Annette Audigé, Khanh Huỳnh, Julian Zacharjasz, Julien Debbache, Yann Kerdiles, Dagmar Gotthardt, Norihiko Takeda, Joachim Fandrey, Lukas Sommer, Veronika Sexl, Christian Stockmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25065-w

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spelling	doaj-95b70bae74314a89afad5e46b32472572021-08-08T11:37:08ZengNature Publishing GroupNature Communications2041-17232021-08-0112111510.1038/s41467-021-25065-wNK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defenceMichal Sobecki0Ewelina Krzywinska1Shunmugam Nagarajan2Annette Audigé3Khanh Huỳnh4Julian Zacharjasz5Julien Debbache6Yann Kerdiles7Dagmar Gotthardt8Norihiko Takeda9Joachim Fandrey10Lukas Sommer11Veronika Sexl12Christian Stockmann13University of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyUniversity of Zurich, Institute of AnatomyCentre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280Institute of Pharmacology and Toxicology, University of Veterinary MedicineDivision of Cardiology and Metabolism, Center for Molecular Medicine, Jichi Medical University, 3311-1 YakushijiInstitut für Physiologie, Universitätsklinikum Essen, Universität Duisburg-EssenUniversity of Zurich, Institute of AnatomyInstitute of Pharmacology and Toxicology, University of Veterinary MedicineUniversity of Zurich, Institute of AnatomyDuring wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.https://doi.org/10.1038/s41467-021-25065-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann
spellingShingle	Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence Nature Communications
author_facet	Michal Sobecki Ewelina Krzywinska Shunmugam Nagarajan Annette Audigé Khanh Huỳnh Julian Zacharjasz Julien Debbache Yann Kerdiles Dagmar Gotthardt Norihiko Takeda Joachim Fandrey Lukas Sommer Veronika Sexl Christian Stockmann
author_sort	Michal Sobecki
title	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_short	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_full	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_fullStr	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_full_unstemmed	NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
title_sort	nk cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.
url	https://doi.org/10.1038/s41467-021-25065-w
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NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

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