Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vi...

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Main Authors: Michael S. Nakazawa, T. S. Karin Eisinger-Mathason, Navid Sadri, Joshua D. Ochocki, Terence P. F. Gade, Ruchi K. Amin, M. Celeste Simon
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10539
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spelling doaj-95b0d41802c54d1d8d017de48e65cd932021-05-11T10:48:05ZengNature Publishing GroupNature Communications2041-17232016-02-017111310.1038/ncomms10539Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growthMichael S. Nakazawa0T. S. Karin Eisinger-Mathason1Navid Sadri2Joshua D. Ochocki3Terence P. F. Gade4Ruchi K. Amin5M. Celeste Simon6Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III Room 456, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USAAbramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III Room 456, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USAAbramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III Room 456, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USAAbramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III Room 456, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USADepartment of Radiology, Perelman School of Medicine at the University of PennsylvaniaHoward Hughes Medical InstituteAbramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III Room 456, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USAHypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo.https://doi.org/10.1038/ncomms10539
collection DOAJ
language English
format Article
sources DOAJ
author Michael S. Nakazawa
T. S. Karin Eisinger-Mathason
Navid Sadri
Joshua D. Ochocki
Terence P. F. Gade
Ruchi K. Amin
M. Celeste Simon
spellingShingle Michael S. Nakazawa
T. S. Karin Eisinger-Mathason
Navid Sadri
Joshua D. Ochocki
Terence P. F. Gade
Ruchi K. Amin
M. Celeste Simon
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
Nature Communications
author_facet Michael S. Nakazawa
T. S. Karin Eisinger-Mathason
Navid Sadri
Joshua D. Ochocki
Terence P. F. Gade
Ruchi K. Amin
M. Celeste Simon
author_sort Michael S. Nakazawa
title Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_short Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_full Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_fullStr Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_full_unstemmed Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_sort epigenetic re-expression of hif-2α suppresses soft tissue sarcoma growth
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo.
url https://doi.org/10.1038/ncomms10539
work_keys_str_mv AT michaelsnakazawa epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT tskarineisingermathason epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT navidsadri epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT joshuadochocki epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT terencepfgade epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT ruchikamin epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
AT mcelestesimon epigeneticreexpressionofhif2asuppressessofttissuesarcomagrowth
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