Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Recent reports have shown the importance of IFN-γ and T-bet+ B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet+ CD4+ cells, i.e., Th1 cells. This study determined the changes in Th1 subsets with metabolic shift and their potential as therapeutic targets in SLE. Com...

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Bibliographic Details
Main Authors: Shigeru Iwata, Mingzeng Zhang, He Hao, Gulzhan Trimova, Maiko Hajime, Yusuke Miyazaki, Naoaki Ohkubo, Yurie Satoh Kanda, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, Atsushi Nagayasu, Shingo Nakayamada, Kei Sakata, Yoshiya Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
T-bet
IFN-γ
fatty acid synthesis
immunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593103/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.593103/full

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