Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)

Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after inject...

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Main Authors: Sumaiah I Hussein, Saleha S. Shubber, Nahi Y . Yaseen
Format: Article
Language:English
Published: University of Baghdad, College of Veterinary Medicine 2019-12-01
Series:The Iraqi Journal of Veterinary Medicine
Subjects:
Online Access:https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/525
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spelling doaj-95acdff367eb422595d4ddfbd6cd61982021-08-04T20:42:18ZengUniversity of Baghdad, College of Veterinary MedicineThe Iraqi Journal of Veterinary Medicine1609-56932410-74092019-12-0143210.30539/iraqijvm.v43i2.525Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)Sumaiah I Hussein0Saleha S. Shubber1Nahi Y . Yaseen21,2Department of Basic sciences, College of Dentistry, University of Baghdad, Iraq, 3Center of Cancer Research and Cytology, Almustansryia UniversityCollege of Veterinary Medicine, Baghdad UniversityCollege of Veterinary Medicine, Baghdad University Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after injection GNPs by two routes, intratumor and intraperitoneal to compare between two methods in mice implanted with mammary adenocarcinoma for 28 days. Atomic Absorption Spectroscopy was used to measure the GNPs concentrations. The results revealed that the GNPs concentrations were significantly (P≤0.05) increased (3.75±1.75, 2.42 ±0.31 ppm) in kidney tissue after intratumor and intraperitoneal administration, respectively, when compared to the other organs (liver and spleen), followed by tumor mass (2.66±0.01, 1.09 ±0.06 ppm) in tissue. While the concentrations of GNPs in spleen and liver were (1.40 ±0.33, 0.726 ±0.01) and (0.602 ±0.03, 0.517 ±0.02) after intratumor and intraperitoneal administration respectively. Also, the experiment showed that the injection by intratumor was more efficient than intraperitonial method for tumor treatment, so, the nanoparticles were cleared by responsible lymphoid organs of body. https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/525Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal.
collection DOAJ
language English
format Article
sources DOAJ
author Sumaiah I Hussein
Saleha S. Shubber
Nahi Y . Yaseen
spellingShingle Sumaiah I Hussein
Saleha S. Shubber
Nahi Y . Yaseen
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
The Iraqi Journal of Veterinary Medicine
Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal.
author_facet Sumaiah I Hussein
Saleha S. Shubber
Nahi Y . Yaseen
author_sort Sumaiah I Hussein
title Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
title_short Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
title_full Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
title_fullStr Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
title_full_unstemmed Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
title_sort bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 (in vivo study)
publisher University of Baghdad, College of Veterinary Medicine
series The Iraqi Journal of Veterinary Medicine
issn 1609-5693
2410-7409
publishDate 2019-12-01
description Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after injection GNPs by two routes, intratumor and intraperitoneal to compare between two methods in mice implanted with mammary adenocarcinoma for 28 days. Atomic Absorption Spectroscopy was used to measure the GNPs concentrations. The results revealed that the GNPs concentrations were significantly (P≤0.05) increased (3.75±1.75, 2.42 ±0.31 ppm) in kidney tissue after intratumor and intraperitoneal administration, respectively, when compared to the other organs (liver and spleen), followed by tumor mass (2.66±0.01, 1.09 ±0.06 ppm) in tissue. While the concentrations of GNPs in spleen and liver were (1.40 ±0.33, 0.726 ±0.01) and (0.602 ±0.03, 0.517 ±0.02) after intratumor and intraperitoneal administration respectively. Also, the experiment showed that the injection by intratumor was more efficient than intraperitonial method for tumor treatment, so, the nanoparticles were cleared by responsible lymphoid organs of body.
topic Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal.
url https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/525
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AT salehasshubber biodistributionofgoldnanoparticlesintumormassanddifferentorgansinimplantedmicewithmammaryadenocarcinomaam3invivostudy
AT nahiyyaseen biodistributionofgoldnanoparticlesintumormassanddifferentorgansinimplantedmicewithmammaryadenocarcinomaam3invivostudy
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