Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)
Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after inject...
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University of Baghdad, College of Veterinary Medicine
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doaj-95acdff367eb422595d4ddfbd6cd61982021-08-04T20:42:18ZengUniversity of Baghdad, College of Veterinary MedicineThe Iraqi Journal of Veterinary Medicine1609-56932410-74092019-12-0143210.30539/iraqijvm.v43i2.525Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study)Sumaiah I Hussein0Saleha S. Shubber1Nahi Y . Yaseen21,2Department of Basic sciences, College of Dentistry, University of Baghdad, Iraq, 3Center of Cancer Research and Cytology, Almustansryia UniversityCollege of Veterinary Medicine, Baghdad UniversityCollege of Veterinary Medicine, Baghdad University Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after injection GNPs by two routes, intratumor and intraperitoneal to compare between two methods in mice implanted with mammary adenocarcinoma for 28 days. Atomic Absorption Spectroscopy was used to measure the GNPs concentrations. The results revealed that the GNPs concentrations were significantly (P≤0.05) increased (3.75±1.75, 2.42 ±0.31 ppm) in kidney tissue after intratumor and intraperitoneal administration, respectively, when compared to the other organs (liver and spleen), followed by tumor mass (2.66±0.01, 1.09 ±0.06 ppm) in tissue. While the concentrations of GNPs in spleen and liver were (1.40 ±0.33, 0.726 ±0.01) and (0.602 ±0.03, 0.517 ±0.02) after intratumor and intraperitoneal administration respectively. Also, the experiment showed that the injection by intratumor was more efficient than intraperitonial method for tumor treatment, so, the nanoparticles were cleared by responsible lymphoid organs of body. https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/525Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sumaiah I Hussein Saleha S. Shubber Nahi Y . Yaseen |
spellingShingle |
Sumaiah I Hussein Saleha S. Shubber Nahi Y . Yaseen Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) The Iraqi Journal of Veterinary Medicine Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal. |
author_facet |
Sumaiah I Hussein Saleha S. Shubber Nahi Y . Yaseen |
author_sort |
Sumaiah I Hussein |
title |
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) |
title_short |
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) |
title_full |
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) |
title_fullStr |
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) |
title_full_unstemmed |
Bio-distribution of Gold Nanoparticles in Tumor Mass and Different Organs in Implanted Mice with Mammary Adenocarcinoma AM3 (in vivo study) |
title_sort |
bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 (in vivo study) |
publisher |
University of Baghdad, College of Veterinary Medicine |
series |
The Iraqi Journal of Veterinary Medicine |
issn |
1609-5693 2410-7409 |
publishDate |
2019-12-01 |
description |
Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity. Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after injection GNPs by two routes, intratumor and intraperitoneal to compare between two methods in mice implanted with mammary adenocarcinoma for 28 days. Atomic Absorption Spectroscopy was used to measure the GNPs concentrations. The results revealed that the GNPs concentrations were significantly (P≤0.05) increased (3.75±1.75, 2.42 ±0.31 ppm) in kidney tissue after intratumor and intraperitoneal administration, respectively, when compared to the other organs (liver and spleen), followed by tumor mass (2.66±0.01, 1.09 ±0.06 ppm) in tissue. While the concentrations of GNPs in spleen and liver were (1.40 ±0.33, 0.726 ±0.01) and (0.602 ±0.03, 0.517 ±0.02) after intratumor and intraperitoneal administration respectively. Also, the experiment showed that the injection by intratumor was more efficient than intraperitonial method for tumor treatment, so, the nanoparticles were cleared by responsible lymphoid organs of body.
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topic |
Gold nanoparticles, In vivo, bio-distribution, intratumor, Intraperitoneal. |
url |
https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/525 |
work_keys_str_mv |
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