Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in a physiological setting by designing novel to...

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Bibliographic Details
Main Authors: Rong Zhu, Walter Sandtner, Joan E. A. Ahiable, Amy Hauck Newman, Michael Freissmuth, Harald H. Sitte, Peter Hinterdorfer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
serotonin transporter
S-citalopram
allosteric binding sites
atomic force microscopy
single molecule force spectroscopy
simultaneous topography and recognition imaging
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00099/full

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