A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male <i>Ldlr <sup>-/-</sup></i> Mice

A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male <i>Ldlr <sup>-/-</sup></i> Mice

Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and primary hepatocellular cancer (HCC). Obesity and type 2 diabetes mellitus (T2DM) are strongly associated with NAF...

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Bibliographic Details
Main Authors: Manuel García-Jaramillo, Kelli A. Lytle, Melinda H. Spooner, Donald B. Jump
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Metabolites
Subjects:
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
arachidonic acid
docosahexaenoic acid
inflammation
fibrosis
lipidomics
mass spectrometry
Online Access:https://www.mdpi.com/2218-1989/9/11/252

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