Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation

Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation

Located contiguously on the long arm of the second chromosome are gene paralogs encoding the immunoglobulin-family co-activation receptors CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4). CD28 and CTLA4 share the same B7 ligands yet each provides opposing proliferative signals to T cell...

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Bibliographic Details
Main Authors: Carole Le Coz, Brian E. Nolan, Melissa Trofa, Alicia M. Kamsheh, Mustafa K. Khokha, Saquib A. Lakhani, Antonio Novelli, Elaine H. Zackai, Kathleen E. Sullivan, Silvana Briuglia, Tricia R. Bhatti, Neil Romberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
cytotoxic T-lymphocyte-associated protein 4
CD28
type 3 innate lymphoid cell
inflammation
regulatory T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01715/full

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