Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies

Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies

Bibliographic Details
Main Authors: Marie-Claire Devilder, Melinda Moyon, Laetitia Gautreau-Rolland, Benjamin Navet, Jeanne Perroteau, Florent Delbos, Marie-Claude Gesnel, Richard Breathnach, Xavier Saulquin
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Biotechnology
Subjects:
Human antibodies
SHM
CRISPR
CRISPR-X
AID
Tetramers
Online Access:http://link.springer.com/article/10.1186/s12896-019-0504-z

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