Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies

Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies

Bibliographic Details
Main Authors: Marie-Claire Devilder, Melinda Moyon, Laetitia Gautreau-Rolland, Benjamin Navet, Jeanne Perroteau, Florent Delbos, Marie-Claude Gesnel, Richard Breathnach, Xavier Saulquin
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Biotechnology
Subjects:
Human antibodies
SHM
CRISPR
CRISPR-X
AID
Tetramers
Online Access:http://link.springer.com/article/10.1186/s12896-019-0504-z
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spelling doaj-95a8770de07242eb82ca1694c57132572020-11-25T03:35:00ZengBMCBMC Biotechnology1472-67502019-02-0119111310.1186/s12896-019-0504-zEx vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodiesMarie-Claire Devilder0Melinda Moyon1Laetitia Gautreau-Rolland2Benjamin Navet3Jeanne Perroteau4Florent Delbos5Marie-Claude Gesnel6Richard Breathnach7Xavier Saulquin8CRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesHLA Laboratory, EFS Centre Pays de la LoireCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de NantesCRCINA, INSERM, CNRS, Université d’Angers, Université de Nanteshttp://link.springer.com/article/10.1186/s12896-019-0504-zHuman antibodiesSHMCRISPRCRISPR-XAIDTetramers
collection DOAJ
language English
format Article
sources DOAJ
author Marie-Claire Devilder
Melinda Moyon
Laetitia Gautreau-Rolland
Benjamin Navet
Jeanne Perroteau
Florent Delbos
Marie-Claude Gesnel
Richard Breathnach
Xavier Saulquin
spellingShingle Marie-Claire Devilder
Melinda Moyon
Laetitia Gautreau-Rolland
Benjamin Navet
Jeanne Perroteau
Florent Delbos
Marie-Claude Gesnel
Richard Breathnach
Xavier Saulquin
Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
BMC Biotechnology
Human antibodies
SHM
CRISPR
CRISPR-X
AID
Tetramers
author_facet Marie-Claire Devilder
Melinda Moyon
Laetitia Gautreau-Rolland
Benjamin Navet
Jeanne Perroteau
Florent Delbos
Marie-Claude Gesnel
Richard Breathnach
Xavier Saulquin
author_sort Marie-Claire Devilder
title Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
title_short Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
title_full Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
title_fullStr Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
title_full_unstemmed Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
title_sort ex vivo evolution of human antibodies by crispr-x: from a naive b cell repertoire to affinity matured antibodies
publisher BMC
series BMC Biotechnology
issn 1472-6750
publishDate 2019-02-01
topic Human antibodies
SHM
CRISPR
CRISPR-X
AID
Tetramers
url http://link.springer.com/article/10.1186/s12896-019-0504-z
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