Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells. Tumor associated macrophages (TAMs) showing functional plasticity contribute to this process as so called M2-like macrophages c...

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Bibliographic Details
Main Authors: David Eisel, Krishna Das, Elke Dickes, Rainer König, Wolfram Osen, Stefan B. Eichmüller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
tumor associated macrophages
CD4+ T cells
tumor microenvironment
adoptive T cell transfer
M2 macrophage
T cell therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00219/full

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