A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

• Main Authors: Nan-Seol Kim, Kyu Sik Kang, Sie Hyeon Yoo, Jin Hun Chung, Ji-Won Chung, Yonghan Seo, Ho-Soon Chung, Hye-Rim Jeon, Hyung Youn Gong, Hyun-Young Lee, Seong-Taek Mun
• Format: Article
• Language: English
• Published: Korean Society of Anesthesiologists 2015-06-01
• Series: Korean Journal of Anesthesiology
• Subjects: fentanyl; oxycodone; postoperative pain
• Online Access: http://ekja.org/upload/pdf/kjae-68-261.pdf

BackgroundWe planned to compare the effect of intravenous oxycodone and fentanyl on post-operative pain after laparoscopic hysterectomy.MethodsWe examined 60 patients were randomized to postoperative pain treatment with either oxycodone (n = 30, Group O) or fentanyl (n = 30, Group F). The patients received 10 mg oxycodone/100 µg fentanyl with ketorolac 30 mg before the end of anesthesia and then continued with patient-controlled analgesia for 48 h postoperatively.ResultsThe accumulated oxycodone consumption was less than fentanyl during 8, 24 and 48 h postoperatively. Numeric rating score of Group O showed significantly lower than that of Group F during 30 min, 2, 4, 8 and 24 h postoperatively. The incidences of adverse reactions were similar in the two groups, though the incidence of nausea was higher in the Group O during the 24 and 48 h postoperative period.ConclusionsOxycodone IV-PCA was more advantageous than fentanyl IV-PCA for laparoscopic hysterectomy in view of accumulated oxycodone consumption, pain control and cost beneficial effect. However, patient satisfaction was not good in the group O compared to group F.