Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

<p>Abstract</p> <p>Background</p> <p>Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival. Reintroduction of PTEN...

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Bibliographic Details
Main Authors: Samimi Goli, Seely B Lynn, Webster Nicholas JG
Format: Article
Language:English
Published: BMC 2002-05-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/2/15

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