Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IG...
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doaj-9587265658f849ccbbaaa31b731422d92020-11-25T00:52:29ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/60575896057589Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung DiseasesZheng Wang0Wenting Li1Qiongya Guo2Yuming Wang3Lijun Ma4Xiaoju Zhang5Department of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Infectious Diseases, Anhui Provincial Hospital, Hefei 230001, ChinaDepartment of Digestive Diseases, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaMedical Research Center, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaInsulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.http://dx.doi.org/10.1155/2018/6057589 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng Wang Wenting Li Qiongya Guo Yuming Wang Lijun Ma Xiaoju Zhang |
spellingShingle |
Zheng Wang Wenting Li Qiongya Guo Yuming Wang Lijun Ma Xiaoju Zhang Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases BioMed Research International |
author_facet |
Zheng Wang Wenting Li Qiongya Guo Yuming Wang Lijun Ma Xiaoju Zhang |
author_sort |
Zheng Wang |
title |
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
title_short |
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
title_full |
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
title_fullStr |
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
title_full_unstemmed |
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
title_sort |
insulin-like growth factor-1 signaling in lung development and inflammatory lung diseases |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases. |
url |
http://dx.doi.org/10.1155/2018/6057589 |
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