Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IG...

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Main Authors: Zheng Wang, Wenting Li, Qiongya Guo, Yuming Wang, Lijun Ma, Xiaoju Zhang
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/6057589
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spelling doaj-9587265658f849ccbbaaa31b731422d92020-11-25T00:52:29ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/60575896057589Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung DiseasesZheng Wang0Wenting Li1Qiongya Guo2Yuming Wang3Lijun Ma4Xiaoju Zhang5Department of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Infectious Diseases, Anhui Provincial Hospital, Hefei 230001, ChinaDepartment of Digestive Diseases, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaMedical Research Center, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaDepartment of Respiratory and Critical Medicine, Zhengzhou University People’s Hospital, Zhengzhou 450003, ChinaInsulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.http://dx.doi.org/10.1155/2018/6057589
collection DOAJ
language English
format Article
sources DOAJ
author Zheng Wang
Wenting Li
Qiongya Guo
Yuming Wang
Lijun Ma
Xiaoju Zhang
spellingShingle Zheng Wang
Wenting Li
Qiongya Guo
Yuming Wang
Lijun Ma
Xiaoju Zhang
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
BioMed Research International
author_facet Zheng Wang
Wenting Li
Qiongya Guo
Yuming Wang
Lijun Ma
Xiaoju Zhang
author_sort Zheng Wang
title Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
title_short Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
title_full Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
title_fullStr Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
title_full_unstemmed Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
title_sort insulin-like growth factor-1 signaling in lung development and inflammatory lung diseases
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.
url http://dx.doi.org/10.1155/2018/6057589
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