Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.

Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.

Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9). In an in vivo glomeru...

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Bibliographic Details
Main Authors: Richard A Steinman, Andria Rasile Robinson, Carol A Feghali-Bostwick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3502367?pdf=render

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