Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases. Although these structures are considered as important parts of the neurovascular unit (NVU),...

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Bibliographic Details
Main Authors: Wolfgang Härtig, Bianca Mages, Susanne Aleithe, Björn Nitzsche, Stephan Altmann, Henryk Barthel, Martin Krueger, Dominik Michalski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Integrative Neuroscience
Subjects:
cerebral ischemia
stroke
animal model
neurovascular unit
extracellular matrix
aggrecan
Online Access:http://journal.frontiersin.org/article/10.3389/fnint.2017.00015/full

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