Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality. Host-derived immunological factors that affect HNSCC tumor development and metastasis are not completely understood. We investigated the...

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Bibliographic Details
Main Authors: Kelvin Anderson, Nathan Ryan, Greta Volpedo, Sanjay Varikuti, Abhay R. Satoskar, Steve Oghumu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
squamous
carcinoma
metastasis
myeloid
suppressor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03095/full

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