The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.

The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.

Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was in Phase III clinical trials for sleep disorder...

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Bibliographic Details
Main Authors: Subhashini Srinivasan, Jeffrey A Simms, Carsten K Nielsen, Steven P Lieske, Jade J Bito-Onon, Henry Yi, Frederic Woodward Hopf, Antonello Bonci, Selena E Bartlett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3448615?pdf=render

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