Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

Abstract Background Age-related macular degeneration (AMD) is a progressive retinal disease contributing to blindness worldwide. Multiple estimates for AMD heritability (h 2 ) exist; however, a substantial proportion of h 2 is not attributable to known genomic loci. The International AMD Genomics Co...

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Bibliographic Details
Main Authors: Andrea R. Waksmunski, Michelle Grunin, Tyler G. Kinzy, Robert P. Igo, Jonathan L. Haines, Jessica N. Cooke Bailey
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Medical Genomics
Subjects:
Genome-wide association study
Pathway analysis
Statistical driver gene
GREML
Heritability
Online Access:http://link.springer.com/article/10.1186/s12920-020-00747-4

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