T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways

T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways

Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early developmental stage lymphocytes. Its expression is deregulated in chronic lymphocytic leukemia (B-CLL) and most lymphomas....

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Bibliographic Details
Main Authors: Francesco Paduano, Eugenio Gaudio, Afua A. Mensah, Sandra Pinton, Francesco Bertoni, Francesco Trapasso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Oncology
Subjects:
T-cell leukemia/lymphoma 1A (TCL1A)
TCL1 interacting partners
CLL and lymphomas
TCL1-positive hematological malignancies
targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00317/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00317/full

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