Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia

Abstract Background Relapsed acute myeloid leukemia (AML) is associated with the acquisition of additional somatic mutations which are thought to drive phenotypic adaptability, clonal selection and evolution of leukemic clones during treatment. We performed high throughput exome sequencing of matche...

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Bibliographic Details
Main Authors: Yuslina Mat Yusoff, Fadly Ahid, Zahidah Abu Seman, Julia Abdullah, Nor Rizan Kamaluddin, Ezalia Esa, Zubaidah Zakaria
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Cytogenetics
Subjects:
Acute myeloid leukemia
Clonal evolution
Mutation
Relapse
Whole exome sequencing
Online Access:https://doi.org/10.1186/s13039-021-00561-2

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