Urethral bulking agent found in a urethral caruncle which did not respond to topical oestrogens: A case report

• Main Authors: Christopher Savvas, George Araklitis, Chirag Shah, Dudley Robinson, Linda Cardozo
• Format: Article
• Language: English
• Published: Elsevier 2020-10-01
• Series: Case Reports in Women's Health
• Subjects: Macroplastique; Urethral bulking agent; Urerthral caruncle
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214911220300989

Background: Urethral caruncles are lesions occurring at the urethral orifice, around the posterior lip of the urethra. They are the most common benign growth of the female urethra. They are often asymptomatic and found incidentally on clinical examination. When symptomatic they commonly present with bleeding. Treatment includes vaginal oestrogens or, failing that, surgical excision. We present an unusual finding after excision of a urethral caruncle. Case: A patient with a background of stress urinary incontinence had numerous pelvic surgeries, including colposuspension, tension-free vaginal tape (TVT) and Macroplastique (a urethral bulking agent). She developed bleeding from a 3 cm urethral caruncle, which did not improve with vaginal oestrogens. She proceeded to have a surgical excision of the caruncle. Histology revealed a foreign material with surrounding foreign-body-type multinucleate giant cell reaction. The material was compatible with Macroplastique. Conclusion: This case report describes an unusual and unexpected histological finding. Macroplastique is injected in the urethra, 10–15 mm from the bladder neck. We suspect the caruncle dragged the Macroplastique material out through the urethral meatus. If urethral caruncles are not adequately treated with vaginal oestrogens, surgery should be considered.