p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of human embryonic stem cells (hESCs) and opposing self...

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Bibliographic Details
Main Authors: Abhinav K Jain, Kendra Allton, Michelina Iacovino, Elisabeth Mahen, Robert J Milczarek, Thomas P Zwaka, Michael Kyba, Michelle Craig Barton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22389628/?tool=EBI

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