Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines

Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines

Nuclear transport receptors, such as karyopherin-β1 (KPNB1), play important roles in the nuclear-cytoplasmic transport of macromolecules. Recent evidence indicates the involvement of nuclear transport receptors in the progression of cancer, making these receptors promising targets for the treatment...

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Bibliographic Details
Main Authors: Masaharu Hazawa, Hironori Yoshino, Yuta Nakagawa, Reina Shimizume, Keisuke Nitta, Yoshiaki Sato, Mariko Sato, Richard W. Wong, Ikuo Kashiwakura
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma
karyopherin-β1
radiosensitization
apoptosis
puma
ΔNp63
Online Access:https://www.mdpi.com/2072-6694/12/4/908

Internet

https://www.mdpi.com/2072-6694/12/4/908

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