Contemporary Network Proteomics and Its Requirements

The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expa...

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Bibliographic Details
Main Authors:	Wilson Wen Bin Goh, Limsoon Wong, Judy Chia Ghee Sng
Format:	Article
Language:	English
Published:	MDPI AG 2013-12-01
Series:	Biology
Subjects:	proteomics networks systems biology bioinformatics
Online Access:	http://www.mdpi.com/2079-7737/3/1/22

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spelling	doaj-952290ec8a1d43fdb2fec87665abbccb2020-11-24T22:33:28ZengMDPI AGBiology2079-77372013-12-0131223810.3390/biology3010022biology3010022Contemporary Network Proteomics and Its RequirementsWilson Wen Bin Goh0Limsoon Wong1Judy Chia Ghee Sng2School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, SingaporeSchool of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, SingaporeDepartment of Physiology, National University of Singapore, 2 Medical Drive, Singapore 117597, SingaporeThe integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.http://www.mdpi.com/2079-7737/3/1/22proteomics networkssystems biologybioinformatics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wilson Wen Bin Goh Limsoon Wong Judy Chia Ghee Sng
spellingShingle	Wilson Wen Bin Goh Limsoon Wong Judy Chia Ghee Sng Contemporary Network Proteomics and Its Requirements Biology proteomics networks systems biology bioinformatics
author_facet	Wilson Wen Bin Goh Limsoon Wong Judy Chia Ghee Sng
author_sort	Wilson Wen Bin Goh
title	Contemporary Network Proteomics and Its Requirements
title_short	Contemporary Network Proteomics and Its Requirements
title_full	Contemporary Network Proteomics and Its Requirements
title_fullStr	Contemporary Network Proteomics and Its Requirements
title_full_unstemmed	Contemporary Network Proteomics and Its Requirements
title_sort	contemporary network proteomics and its requirements
publisher	MDPI AG
series	Biology
issn	2079-7737
publishDate	2013-12-01
description	The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.
topic	proteomics networks systems biology bioinformatics
url	http://www.mdpi.com/2079-7737/3/1/22
work_keys_str_mv	AT wilsonwenbingoh contemporarynetworkproteomicsanditsrequirements AT limsoonwong contemporarynetworkproteomicsanditsrequirements AT judychiagheesng contemporarynetworkproteomicsanditsrequirements
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Contemporary Network Proteomics and Its Requirements

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