Contemporary Network Proteomics and Its Requirements

The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expa...

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Bibliographic Details
Main Authors: Wilson Wen Bin Goh, Limsoon Wong, Judy Chia Ghee Sng
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Biology
Subjects:
Online Access:http://www.mdpi.com/2079-7737/3/1/22
Description
Summary:The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.
ISSN:2079-7737