N-palmitoyl-D-glucosamine, a Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice

N-palmitoyl-D-glucosamine, a Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice

Toll-like receptors (TLRs) are key receptors through which infectious and non-infectious challenges act with consequent activation of the inflammatory cascade that plays a critical function in various acute and chronic diseases, behaving as amplification and chronicization factors of the inflammator...

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Bibliographic Details
Main Authors: Monica Iannotta, Carmela Belardo, Maria Consiglia Trotta, Fabio Arturo Iannotti, Rosa Maria Vitale, Rosa Maisto, Serena Boccella, Rosmara Infantino, Flavia Ricciardi, Benito Fabio Mirto, Franca Ferraraccio, Iacopo Panarese, Pietro Amodeo, Lea Tunisi, Luigia Cristino, Michele D’Amico, Vincenzo Di Marzo, Livio Luongo, Sabatino Maione, Francesca Guida
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
N-palmitoyl-D-glucosamine
LPS
TLR4
cytokines
peripheral neuropathy
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/3/1491

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