Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.

Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.

Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms--GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated. We found tha...

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Main Authors: Márcio S Baptista, Carlos V Melo, Mário Armelão, Dennis Herrmann, Diogo O Pimentel, Graciano Leal, Margarida V Caldeira, Ben A Bahr, Mário Bengtson, Ramiro D Almeida, Carlos B Duarte
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2853570?pdf=render

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