Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

Obesity is linked with altered microbial short-chain fatty acids (SCFAs), which are a signature of gut dysbiosis and inflammation. In the present study, we investigated whether tributyrin, a prodrug of the SCFA butyrate, could improve metabolic and inflammatory profiles in diet-induced obese mice. M...

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Bibliographic Details
Main Authors: Fabio Takeo Sato, Yu Anne Yap, Amanda Rabello Crisma, Mariana Portovedo, Gilson Masahiro Murata, Sandro Massao Hirabara, Willian Rodrigues Ribeiro, Caroline Marcantonio Ferreira, Maysa Mariana Cruz, Joice Naiara Bertaglia Pereira, Tanyara Baliani Payolla, Suzana Eiko Sato Guima, Andrew Maltez Thomas, João Carlos Setubal, Maria Isabel Cardoso Alonso-Vale, Marinilce Fagundes Santos, Rui Curi, Eliana Marino, Marco A. R. Vinolo
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
butyrate
microbiota
insulin resistance
dysbiosis
Online Access:https://www.mdpi.com/2073-4409/9/9/2007

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