Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis

Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis

Summary: Mouse embryonic stem cell (ESC) pluripotency is tightly regulated by a complex network composed of extrinsic and intrinsic factors that allow proper organismal development. O-linked β-N-acetylglucosamine (O-GlcNAc) is the sole glycosylation mark found on cytoplasmic and nuclear proteins and...

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Bibliographic Details
Main Authors: Federico Pecori, Nanako Kondo, Chika Ogura, Taichi Miura, Masahiko Kume, Youhei Minamijima, Kazuo Yamamoto, Shoko Nishihara
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
Ddx6
embryonic stem cells
glycosylation
O-GlcNAc
P-bodies
pluripotency
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007592

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