Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Background: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence in patients with chronic HBV infection. Understanding the mechanisms underlying stability and persistence of HBV cccDNA in hepatocytes is critical for developing novel therapeutics...

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Bibliographic Details
Main Authors: Sergey Brezgin, Anastasiia Kostyusheva, Ekaterina Bayurova, Ilya Gordeychuk, Maria Isaguliants, Irina Goptar, Anastasiia Nikiforova, Valery Smirnov, Elena Volchkova, Dieter Glebe, Dmitry Kostyushev, Vladimir Chulanov
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Microorganisms
Subjects:
cccdna
rcdna
maintenance
persistence
innate immunity
viral replication
dna damage
methylation
crispr/cas9
dnmt3a
gene editing
Online Access:https://www.mdpi.com/2076-2607/7/11/533

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