Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19

Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19

Abstract Background Air pollution exposure and idiopathic pulmonary fibrosis (IPF) cause a poor prognosis after SARS-CoV-2 infection, but the underlying mechanisms are not well explored. Angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the keys to the entry of...

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Bibliographic Details
Main Authors: Hsin-Hsien Li, Chen-Chi Liu, Tien-Wei Hsu, Jiun-Han Lin, Jyuan-Wei Hsu, Anna Fen-Yau Li, Yi-Chen Yeh, Shih-Chieh Hung, Han-Shui Hsu
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Particle and Fibre Toxicology
Subjects:
Air pollution
Idiopathic pulmonary fibrosis
COVID-19
ACE2
TMPRSS2
Online Access:https://doi.org/10.1186/s12989-021-00404-3

Internet

https://doi.org/10.1186/s12989-021-00404-3

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