Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality.

Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality.

Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate. Detailed timed pregnancy analysis of embryos showed that the lethality occurred between embryonic day 3.5 pc and 5.5 pc, a period of implan...

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Bibliographic Details
Main Authors: Yong Kim, Jim McBride, Lauren Kimlin, Eung-Kwon Pae, Amit Deshpande, David T Wong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2641017?pdf=render

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