Role of p53 in the Regulation of Cellular Senescence

Role of p53 in the Regulation of Cellular Senescence

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle a...

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Bibliographic Details
Main Authors: Mahmut Mijit, Valentina Caracciolo, Antonio Melillo, Fernanda Amicarelli, Antonio Giordano
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
p53
senescence
cell cycle arrest
microenvironment
dna damage.
Online Access:https://www.mdpi.com/2218-273X/10/3/420

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