A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

Radix Angelicae dahuricae, containing coumarins, which might affect cytochrome P450 enzyme (CYP450) activity, has been co-administered with ligustrazine, a substrate of CYP450s, for the clinical treatment of migraine. However, whether a pharmacokinetic-based synergy exists between Radix Angelicae da...

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Bibliographic Details
Main Authors:	Shan Feng, Xin He, Peiru Zhong, Jinyi Zhao, Cong Huang, Zhuohan Hu
Format:	Article
Language:	English
Published:	MDPI AG 2018-04-01
Series:	Molecules
Subjects:	CYP 450s ligustrazine migraine Radix Angelicae dahuricae synergy
Online Access:	http://www.mdpi.com/1420-3049/23/5/1004

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