Cytoplasmic Interactions between the Glucocorticoid Receptor and HDAC2 Regulate Osteocalcin Expression in VPA-Treated MSCs

Cytoplasmic Interactions between the Glucocorticoid Receptor and HDAC2 Regulate Osteocalcin Expression in VPA-Treated MSCs

Epigenetic regulation has been considered an important mechanism for influencing stem cell differentiation. In particular, histone deacetylases (HDACs) have been shown to play a role in the osteoblast differentiation of mesenchymal stem cells (MSCs). In this study, the effect of the HDAC inhibitor,...

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Bibliographic Details
Main Authors: Marcella La Noce, Luigi Mele, Luigi Laino, Giovanni Iolascon, Gorizio Pieretti, Gianpaolo Papaccio, Vincenzo Desiderio, Virginia Tirino, Francesca Paino
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
epigenetic drug
glucocorticoid receptor
HDAC2
human mesenchymal stem cells
osteogenic differentiation
Online Access:http://www.mdpi.com/2073-4409/8/3/217

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http://www.mdpi.com/2073-4409/8/3/217

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